Spatial organization of tissue-resident memory T cells
Year: 2026
Type: article
Abstract: Summary Tissue-resident memory T (TRM) cells durably reside in peripheral tissues, poised to deliver rapid local immune protection. TRM cells are found in most organs, and they are a core component of immunological memory, complementing circulating memory T cell populations. By definition, TRM cells can persist in tissues for months to years without antigen stimulation. However, demonstrating both residency and antigen absence in reality is challenging. Here, we discuss the strengths and challenges to our canonical definitions of TRM cells. We examine how early priming and subsequent tissue imprinting impact TRM cell programming. Finally, we underline the intra-tissue heterogeneity of TRM cells and provide a framework for resolving niche-level cues and refining TRM classification.
Source: Immunity
Authors: Thomas N. Burn, Laura K. Mackay
Institutions: The University of Melbourne, Peter Doherty Institute
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $10,400
OpenAlex ID: W7154304608