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A study on cortical habituation based on event-related potential P50 and CNV

Year: 2026

Type: article

Abstract: This study systematically evaluated electrophysiological alterations in early sensory gating and late cognitive anticipation functions in migraine patients using the P50 and Correlated Negative Variation (CNV) components of event-related potentials (ERPs). Findings revealed: - Under the P50 paradigm, patients exhibited prolonged latencies and increased suppression rates, indicating impaired sensory gating. - Under the CNV paradigm, patients demonstrated prolonged latencies across multiple components, along with significantly increased occipital iCNV amplitude and CNV area values, reflecting slowed information processing and heightened cortical excitability. - Enhanced theta and alpha band energy was observed across extensive brain regions in both paradigms. These results indicate that migraine patients exhibit impaired cortical inhibitory function and abnormal information processing throughout the entire pathway, from early sensory gating to late cognitive anticipation. This electrophysiological profile provides an objective, quantitative neurobiological marker for migraine-related cognitive impairment, holding potential value for clinical diagnosis and monitoring.

Source: Frontiers in Neurology

DOI: 10.3389/fneur.2026.1787063