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Immune checkpoint inhibitor-induced myocarditis with atrioventricular conduction abnormalities: a case report

Year: 2026

Type: article

Abstract: Immune checkpoint inhibitors (ICIs) are increasingly used in the treatment of several cancer types, but can cause immune-related adverse events (irAEs) such as myocarditis. ICI-induced myocarditis is rare but potentially life threatening and may present with subtle or atypical symptoms, including conduction abnormalities. We describe a case of nivolumab-induced myocarditis in a patient receiving adjuvant therapy for esophageal cancer, presenting with high-grade atrioventricular block and neuromuscular symptoms, highlighting the diagnostic and therapeutic challenges of ICI-induced myocarditis. The case underscores the importance of early recognition, comprehensive diagnostic evaluation, prompt initiation of immunosuppressive therapy, and individualized management of conduction disturbances. Early detection and intervention are key to mitigating risks and improving outcomes in this rare but serious irAE.

Source: ESMO Gastrointestinal Oncology

DOI: 10.1016/j.esmogo.2026.100320

Authors: A. Strijdhorst, T.S.J. Opstal, L.F.H.J. Robbers, M. Labots, H.W.M. van Laarhoven