Work

Pd(II)-Catalyzed C–H Activation/ O -Annulation toward Succinimide-Embedded Tetracyclic Pyranonaphthoquinones and Their Application as Metal Sensors

Year: 2026

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide A Pd(II)-catalyzed cascade C–H activation/ O -annulation strategy is developed for the efficient synthesis of succinimide-integrated tetracyclic pyranonaphthoquinones using 3-aryl-2-hydroxy naphthoquinones with maleimides or itaconimides as substrates. This methodology provides a fast and efficient approach to prepare diverse tetracyclic pyranonaphthoquinones featuring spirosuccinimides or succinimide motifs via [5 + 1] cycloaddition. Notably, one of the synthesized compounds exhibited high sensitivity and selectivity as a fluorescent chemosensor for Fe 3+ ions, achieving a low detection limit of 30.07 × 10 –9 M.

Source: ACS Omega

DOI: 10.1021/acsomega.6c02786

Authors: Eswaran Kamaraj, Amrendra Kumar, Sonaimuthu Mohandoss, Raju S. Thombal, Hee Nam Lim, Yong Rok Lee

Institution: Yeungnam University

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,935

Funders: National Research Foundation, National Research Foundation of Korea