Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy
Year: 2026
Type: article
Abstract: ABSTRACT Despite decades of intense research, cancer remains a major global health challenge, with a clear need for new and more efficient therapies. Among emerging approaches, high atomic number (Z) nanomaterials capable of modulating the interaction between radiation and matter have attracted growing interest as radiotherapy enhancers. In this work, ultra‐small Platinum‐based nanoparticles with a metallic core diameter of 2–3 nm were synthesized from H 2 PtCl 6 using polyvinylpyrrolidone as stabilizer. This nanomaterial exhibits low acute toxicity, catalase‐like activity and enhances DNA damage under pre‐clinical X‐ray irradiation, increasing the antitumoral effect of X‐ray alone. In vitro and in vivo studies, including intratumoral and intravenous administration, demonstrate improved tumor control and prolonged survival without detectable systemic toxicity under the tested conditions, establishing ultra‐small Pt‐nanoparticles as efficient materials for radiotherapy enhancement.
Source: Advanced Functional Materials
Institutions: Universidad de Zaragoza, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, Instituto de Nanociencia y Materiales de Aragón, Instituto de Investigación Sanitaria Aragón, Spanish National Cancer Research Centre, Instituto de Salud Carlos III, Universitat de Miguel Hernández d'Elx, Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE)
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,790
Funders: Ministerio de Ciencia, Innovación y Universidades, Ministerio de Economía y Competitividad, Ministerio de Ciencia e Innovación, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Universidad de Zaragoza, Instituto de Salud Carlos III, European Regional Development Fund, Agencia Estatal de Investigación
Awards: G1270149831, G1610934229, G1622782223, G2072863431, G2262748287, Uso de Vesículas Extracelulares que expresan NIS para la teragnosis de tumores infantiles., G2799588417, G294895050, G3082032993, G3295751965, G3480869486, G425668148, G4293424916, G451917667, G4526231891, G464105488, G4704457972, G5635532810, G586857820, G5967599077, G6033112984, G6057404856, G7084143925, G7416259672, G7538928026, G7552661539, G7863371703, G8430294048, G8497050386, G8667377315, G983705713
OpenAlex ID: W7154335014