Year: 2026
Type: article
Abstract: ABSTRACT While conventional methods to 11 C‐ and 18 F‐labelled radiopharmaceuticals utilize a vial‐based approach, in the past quarter‐century, a modern, efficient, and cleaner “loop method” has been developed. This Perspective will shed light on the history behind the development of the loop radiochemistry method, the multifold advantages associated with the method over other approaches, its applications to the synthesis of 11 C‐ and 18 F‐labelled compounds and radiopharmaceuticals for preclinical and human PET imaging studies, its eventual expansion to diverse organic chemistry reactions and finally provide a future outlook for further developments in this field of radiochemistry.
DOI: 10.1002/jlcr.70029
Authors: Emily Murrell, Sahil Khan, Neil Vasdev
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,800
OpenAlex ID: W7154378642