Work

Nirmatrelvir methyl tert -butyl ether solvate

Year: 2026

Type: article

Abstract: The structure of nirmatrelvir MTBE solvate, C 23 H 32 F 3 N 5 O 4 ·C 5 H 12 O, at 150 K has monoclinic ( P 2 1 ) symmetry. The asymmetric unit contains one nirmatrelvir molecule and one methyl tert -butyl ether solvent molecule. The extended structure consists of N—H...O hydrogen bonds that create create [010] chains. Crystals of the title compound were grown from various methyl tert -butyl ether–methanol solvent mixtures, with crystal morphology dependent upon the mixture ratio.

Source: Acta Crystallographica Section E Crystallographic Communications

DOI: 10.1107/s2056989026003816

Authors: Jared P. Smit, Dale K. Purcell, David A. Engers, Pamela A. Smith, Haley C. Bauser, Adrian Radocea

Institution: Improved Pharma (United States)

Language: English

Topic: Crystal structures of chemical compounds

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $500

OpenAlex ID: W7154389323

FWCI:

Cites: 12

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