Year: 2026
Type: article
Abstract: This short review acknowledges the scientific contribution of Roger Cooke and colleagues, who first introduced the idea of two different biochemical states in resting skeletal muscle thick filament. In a seminal paper published in 2010, the state defined as myosin "super relaxed state" (SRX) has been proposed as the biochemical counterpart of the structural motif named interacting head motif (IHM). This connection has been challenged and revised multiple times, leading to misunderstandings and improper assumptions. In this review, we discuss the recent history of the structure-biochemistry relationship associated with resting myosin thick filament, its current interpretation, and how this is possibly related to future myosin resting state studies.
Source: Biophysical Reviews
Authors: Leonardo Nogara, Carlo Reggiani
Institution: University of Padua
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,990
Funder: Università degli Studi di Padova
OpenAlex ID: W7154400995