Work

When Selectivity Increases Uncertainty: Context‐Dependent Pharmacology in Antibody Drug Development

Year: 2026

Type: article

Abstract: As antibody therapeutics become increasingly selective and multi-specific, their pharmacological effects depend more strongly on biological context, creating new uncertainties in drug development. In this perspective, we discuss how context-dependent pharmacology complicates preclinical-to-clinical translation, dose optimization, and rational combination therapy selection for antibody drugs. Recognizing context dependence is essential for realizing the full therapeutic potential of highly selective biologics and for advancing a more predictive, mechanism-informed paradigm in antibody drug development.

Source: Clinical and Translational Science

DOI: 10.1111/cts.70556

Authors: Xiaozhi Liao, Yanguang Cao

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,630