Geometric Optimization of GMR Biosensors with Trapezoidal Magnetic Flux Concentrators for Detecting Bacillus anthracis in Complex Matrices
Year: 2026
Type: article
Abstract: . Addressing these analytical bottlenecks, we constructed a giant magnetoresistive (GMR) biosensor incorporating geometrically tailored trapezoidal magnetic flux concentrators (MFCs). 3D finite element magnetic simulations directed the MFC topology to mitigate edge saturation, reconciling central magnetic gain with spatial uniformity. The resulting platform demonstrated a 100-fold sensitivity improvement over recent electrochemical methods, achieving a limit of detection (LOD) of 10 CFU/mL in standard buffers, with the entire testing process completed within 40 min. Direct target quantification remained viable in heterogeneous matrices-muddy water, whole milk, and apple cider-circumventing tedious pretreatment. This geometric and magnetic optimization yields a pragmatic sensing architecture tailored for on-site biodefense monitoring.
Source: Sensors
DOI: 10.3390/s26082424
Language: English
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,137
Funders: British Columbia Innovation Council, National Natural Science Foundation of China, Natural Science Foundation of Guangxi Province, Shanghai Jiao Tong University, Natural Science Foundation of Shandong Province, National Key Research and Development Program of China, National Defense Basic Scientific Research Program of China
OpenAlex ID: W7154452687