Work

Successful management approach for Wilms tumor metastatic to the skull treated with regimen I chemotherapy in 10th week: A case report

Year: 2026

Type: article

Abstract: Wilms tumor is the most common pediatric renal malignancy, while skull metastasis is rare, occurring in fewer than 2% of cases. We report a five-year-old girl with stage II anaplastic nephroblastoma who developed skull metastasis two months after radical nephrectomy. She received 24 weeks of regimen I chemotherapy. The skull mass regressed by week six and completely resolved by week ten, with full closure of the exposed area by week eighteen. Adverse effects included alopecia, nausea, anemia, and leukopenia. Post-treatment imaging showed no residual skull lesion. Regimen I demonstrated an effective therapeutic response in this rare presentation.

Source: Urology Case Reports

DOI: 10.1016/j.eucr.2026.103443

Authors: Buyung Prasetyawan, Kurnia Penta Seputra, Pradana Nurhadi

Institutions: University of Brawijaya, RSUD Prof. Dr. Saiful Anwar Malang

Language: English

Topic: Renal and related cancers

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,160