Pulsed Field Ablation for the Interventional Treatment of Atrial Fibrillation. A Scientific Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), the Latin American Heart Rhythm Society (LAHRS) and the Canadian Heart Rhythm Society (CHRS).
Year: 2026
Type: article
Abstract: Pulsed field ablation has emerged as a novel non-thermal treatment modality with a distinct safety profile for the interventional treatment of atrial fibrillation. By inducing irreversible electroporation, pulsed field ablation achieves myocardial ablation while preserving surrounding structures such as nerves, vasculature, and the esophagus. This European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC) scientific statement, endorsed by major international societies, reviews the biophysics, technology, clinical evidence, workflow, safety, and training aspects of pulsed field ablation. Randomized trials demonstrate comparable efficacy to radiofrequency and cryoballoon ablation, with advantages in safety and efficiency. The statement provides practical advice for clinical implementation, operator training, and identifies key gaps in evidence and priorities for future research and innovation.
DOI: 10.48620/96934
Authors: Kühne, Michael, Badertscher, Patrick, Andrade, Jason G, Anic, Ante, Chun, Julian, Dello Russo, Antonio, Jais, Pierre, Kautzner, Josef, Lehrmann, Heiko, Martin, Claire, Merino, Jose, Miklavcic, Damijan, Natale, Andrea, Neven, Kars, Perez-Silva, Armando, Piccini, Jonathan, Reichlin, Tobias, Rosso, Raphael, Ruwald, Martin, Sarkozy, Andrea, Scherr, Daniel, Sultan, Arian, Tada, Hiroshi, Tzeis, Stylianos, Verma, Atul, Wilsmore, Bradley, Pürerfellner, Helmut
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7154469201
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