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Repeated semaglutide treatment attenuates cocaine-vs-food choice in male and female rats

Year: 2026

Type: article

Abstract: The present study determined the effectiveness of the glucagon-like peptide 1 agonist semaglutide to attenuate cocaine-vs-food choice in male and female rats. Repeated 5-day semaglutide treatment decreased cocaine choice and significantly reduced body weight. These preclinical results support the clinical evaluation of semaglutide as a candidate cocaine use disorder medication.

Source: Neuropsychopharmacology

DOI: 10.1038/s41386-026-02386-2

Authors: Nicholas Heslep, Samuel A. Marsh, Matthew L. Banks

Institutions: Virginia Commonwealth University, Virginia Commonwealth University Medical Center

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,290