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Formulation and Evaluation of Glimepiride 4 Mg. Sustained Release Tablets

Year: 2026

Type: article

Abstract: The present study was aimed at the formulation and evaluation of Glimepiride 4 mg sustained release tablets to enhance therapeutic efficacy and improve patient compliance. Glimepiride, a third-generation sulfonylurea, is widely used in the treatment of Type 2 Diabetes Mellitus. Due to its short biological half-life and requirement for prolonged glycemic control, sustained release formulations were developed using hydrophilic polymers such as HPMC K100M and carbapol 934P. The SR- Tablets were prepared by wet granulation method and evaluated for pre-compression and post-compression parameters. And In-vitro dissolution studies were performed for 12 hours, and release kinetics were analyzed. The optimized formulation showed controlled drug release with good physicochemical properties, indicating suitability for sustained release therapy.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.19592141

Author: Dr. Vinod D. Usnale1*, Ms. Nila Priti Baswaraj1, Patel Kaif Altaf1, Palak Devi1, Pandhare Payal Sunil1, Murkute Vishwajeet Vilas1

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7154477208

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