Work

Electrospun nanofibers for gastric cancer: local therapeutics, biomimetic models, and diagnostic interfaces

Year: 2026

Type: article

Abstract: Electrospun nanofibers have emerged as a versatile local-regional platform for gastric cancer, particularly for postoperative recurrence control and peritoneal metastasis, where systemic therapies often fail to achieve sufficient and durable intraperitoneal exposure. Owing to their high surface area, interconnected porosity, and engineerable architecture, electrospun membranes enable programmable local pharmacokinetics and tunable cell-material interactions by regulating fiber diameter, pore connectivity, and alignment. Advanced designs, including coaxial, Janus, multilayer, gradient, and porous fibers, further expand the therapeutic window by separating drug compatibility from release behavior and supporting sequential or compartmentalized delivery. In perioperative settings, electrospun patches can function as locoregional depots to suppress microscopic residual disease while simultaneously facilitating infection control and tissue repair. For peritoneal metastasis, electrospun membranes can sustain intraperitoneal drug exposure and incorporate microenvironment-responsive sensitization strategies targeting hypoxia, redox adaptation, and ferroptosis resistance. Beyond therapy, electrospun scaffolds provide biomimetic gastric cancer models that better recapitulate diffusion barriers, metabolic gradients, and mechanobiological cues, improving the translational relevance of drug-response evaluation. Nanofiber-based interfaces also support longitudinal monitoring by enhancing the capture and analysis of circulating tumor cells and other low-abundance biomarkers. Finally, we highlight key translational considerations, including quality-by-design, critical quality attributes, sterilization robustness, and scalable manufacturing, to accelerate clinical adoption of electrospun products for gastric cancer management.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2026.1795748

Authors: Zhao Wang, Yuanyuan Liu, Yihui Li, Jiangong Wang

Institutions: Tangshan People's Hospital, North China University of Science and Technology, North China University of Science and Technology Affiliated Hospital

Language: English

Topic: Electrospun Nanofibers in Biomedical Applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801