Work

Network hypermotifs in biological systems: structure, dynamics, and functional implications

Year: 2026

Type: article

Abstract: Biological networks exhibit complex structural organization, from motifs, which are recurring patterns of gene, protein, and molecular interactions, to higher order assemblies such as hypermotifs. Hypermotifs are statistically significant higher order assemblies formed through interactions and combinations of motifs, giving rise to collective structural and functional properties. This review discusses hypermotifs in biological networks, focusing on their structure, dynamics, functions, and patterns such as motif clustering and motif generalizations.

Source: npj Systems Biology and Applications

DOI: 10.1038/s41540-026-00701-7

Authors: Moirangthem Sailash Singh, Priyan Bhattacharya, Karthik Raman

Institutions: Indian Institute of Technology Madras, AstraZeneca (India)

Language: English

Topic: Bioinformatics and Genomic Networks

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,490

OpenAlex ID: W7154496474