Work

Value of different nutritional and inflammatory markers for diagnosis of peritonitis in patients undergoing peritoneal dialysis

Year: 2026

Type: article

Abstract: This retrospective study evaluated hematological, inflammatory, and nutritional indicators of peritonitis in 132 peritoneal dialysis (PD) patients, including 83 with confirmed peritonitis and 49 without peritonitis. The peritonitis group had a higher platelet-to-albumin ratio (PAR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune-inflammation index (SIRI), but lower levels of hemoglobin, cholesterol, hematocrit, albumin, lymphocytes, triglycerides, and uric acid (all p < 0.05). Multivariate logistic regression identified hemoglobin (OR = 0.944, p < 0.05) and albumin (OR = 0.719, p < 0.01) as protective factors, and C-reactive protein (CRP; OR = 1.053, p < 0.01) as an independent risk factor. ROC analysis revealed moderate diagnostic performance for PAR (AUC = 0.700), NLR (AUC = 0.718), MLR (AUC = 0.717), and SIRI (AUC = 0.688), but the neutrophil-to-monocyte ratio (NMR) and lymphocyte-to-monocyte ratio (LMR) performed poorly. A combined PAR/NLR/MLR/SIRI model achieved an AUC of 0.798. These findings link poor nutrition and heightened inflammation to peritonitis in PD patients, suggesting blood-derived indices, such as PAR, NLR, MLR, and SIRI, may serve as adjunctive markers to assist the established diagnostic methods.

Source: Renal Failure

DOI: 10.1080/0886022x.2026.2650574

Authors: Xing-Yu Chen, Yu-Lu Fan, Jian Hao

Institution: Inner Mongolia Medical University

Language: English

Topic: Dialysis and Renal Disease Management

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,306