Work

The relationship between IL-10 levels, gene polymorphisms and histiocytic necrotizing lymphadenitis in children

Year: 2026

Type: article

Abstract: BACKGROUND: It has been reported that interleukin-10 (IL-10) is associated with some immune-mediated diseases; however, its relationship with histiocytic necrotizing lymphadenitis (HNL) has not been reported. This study aimed to preliminarily investigate the relationship between IL-10 and HNL. METHODS: This study included 35 children with HNL and 35 healthy controls. Plasma IL-10 levels were detected by ELISA. The gene polymorphisms at -1082A/G, -819T/C, and -592 A/C in the IL-10 promoter were analyzed by Sanger sequencing. Differences in IL-10 expression, allele and genotype frequencies between the two groups were statistically compared. RESULTS: IL-10 levels were significantly higher in children with HNL than in the control group (P = 0.001). However, no significant differences were observed between the two groups in allele frequencies, genotype distributions of the three IL-10 promoter polymorphisms, or the haplotypes constituted by these loci. CONCLUSIONS: These findings suggest that IL-10 may contribute to HNL pathogenesis, while no significant association between the IL-10 promoter polymorphisms (-1082A/G, -819T/C, -592A/C) and pediatric HNL susceptibility was found in this exploratory analysis. A potential genetic association cannot be excluded and further studies with a larger sample size are warranted.

Source: BMC Pediatrics

DOI: 10.1186/s12887-026-06760-3

Authors: Liyan Liu, Hualei Bai, Zhijie Xing, Jian Li

Institutions: Shandong University, Jinan Infectious Disease Hospital

Language: English

Topic: Lymphadenopathy Diagnosis and Analysis

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090