Work

Integrated study reveals molecular mechanisms by which bisphenol A promotes ovarian cancer

Year: 2026

Type: article

Abstract: . Functional analysis indicated that the risk model and its constituent genes are associated with humoral immune activation and cellular immunosuppression. Furthermore, the activation of neuroactive ligand-receptor interaction signaling appears to be a common molecular mechanism through which these risk genes contribute to OC. Molecular docking, molecular dynamics simulations, and cellular experiments confirmed a stable binding interaction between BPA and the CDKN1B protein. These findings provide scientific data for a deeper understanding of the molecular mechanisms linking BPA to OC, aiding risk prediction and personalized prevention for exposed individuals.

Source: iScience

DOI: 10.1016/j.isci.2026.115768

Authors: Haiyan Geng, Jianjun Zhu, Wentao Zhang, Ming Liu

Institutions: Shanxi Medical University, Chinese Academy of Medical Sciences & Peking Union Medical College, Shanxi Provincial Cancer Hospital

Language: English

Topic: Effects and risks of endocrine disrupting chemicals

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240