Work

Association of baseline eosinophil counts with clinical prognosis in cancer patients undergoing immune checkpoint inhibitor therapy

Year: 2026

Type: article

Study designs: Systematic Review, Meta-Analysis

Abstract: Baseline eosinophil indices can capture host immune tone during immune checkpoint inhibitor (ICI) therapy. We synthesized evidence from 30 studies (4,385 patients) to quantify how baseline absolute (AEC) and relative eosinophil count (REC) relate to outcomes. Compared with lower AEC, high AEC was associated with longer overall survival (OS) and progression-free survival (PFS), higher disease control, and objective response, and increased immune-related adverse events. High REC likewise predicted improved OS and PFS. These results position routine eosinophil measures as low-cost biomarkers for prognostic stratification and for balancing expected benefit with toxicity risk in cancer immunotherapy.

Source: iScience

DOI: 10.1016/j.isci.2026.115765

Authors: Wanrong Jiang, Tinghui Mo, Chen Chen, Jiarui Feng, Weixing Wang

Institutions: Wuhan University, Renmin Hospital of Wuhan University

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240