Molecular profiling of gene-edited cells reveals shared drug-resistance mechanisms
Year: 2026
Type: article
Abstract: A platform for tracking the changes in gene expression and chromatin accessibility that follow interference with specific genes has been developed. The platform, called PerturbFate, was applied to skin-cancer cells and showed that different genetic perturbations associated with tumour resistance push cells into a shared dedifferentiated state. Many genetic perturbations that cause resistance to an anticancer drug do so through common pathways.
Source: Nature
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $12,690
OpenAlex ID: W7154513192