Hemodynamic changes in response to GLP-1 treatment in ICD and CRT patients: insights from HeartLogic sensor data
Year: 2026
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Glucagon-like peptide-1 receptor agonist (GLP-1RA) therapy is increasingly used, but the physiological effects in patients with heart failure and reduced ejection fraction (HFrEF) remain uncertain. Continuously collected data from implantable cardiac devices may enable evaluation of drug effects in a real-world setting. METHODS: In a nationwide Danish retrospective matched cohort study, GLP-1RA initiators with implantable cardiac devices were matched 1:5 to unexposed device recipients by sex and age. Sensor data were assessed from 30 days before to 30 days after initiation. Primary outcomes were changes in heart rate and thoracic impedance. Analyses were adjusted for baseline sensor value, BMI category, hypertension, and type 2 diabetes. Prespecified subgroup analyses were performed in patients with HFrEF. RESULTS: In 666 patients (111 GLP-1RA initiators, 555 matched controls), semaglutide was used in 95% of initiators. Compared with controls, GLP-1RA initiation was associated with higher night heart rate (adjusted difference 2.12 bpm; 95% CI, 1.38-2.87), higher daily heart rate (1.46 bpm; 95% CI, 0.65-2.06), and higher thoracic impedance (0.66 Ω; 95% CI, 0.17-1.15) (all P < .01). S1 amplitude decreased (-0.09 mG; 95% CI, -0.14 to -0.04; P < .01). Heart rate increases followed a stepwise pattern across semaglutide dose levels, with an average increase of 2.5 bpm per dose escalation. Findings were directionally consistent in patients with HFrEF (GLP-1RA n = 80), with no evidence of effect modification. CONCLUSION: GLP-1RA initiation was associated with measurable changes in device-derived physiology. Larger studies are needed to evaluate clinical implications, including in HFrEF.
DOI: 10.1093/ejhf/xuag114
Authors: Frederik Holme Fussing, Lise Witten Davodian, Danny Witten Davodian, Niklas Dyrby Johansen, Preman Kumarathurai, Daniel Modin, Stefan Sattler, Charlotte Larroudé, Niels Risum, Michael Vinther, Lars Køber, Kasper Rossing, Mads Ersbøll, Mikael Kjær Poulsen, Brian Bridal Løgstrup, Katja Fiedler Holm, Ketil J Haugan, Christopher Chien, Brian Claggett, Scott Solomon, Marat Fudim, Adrian Hernandez, Tarek Bekfani, Jens Brock Johansen, Jens Cosedis Nielsen, Craig M Stolen, Tor Biering-Sørensen
Institutions: University of Copenhagen, Herlev Hospital, Copenhagen University Hospital, Gentofte Hospital, Odense University Hospital, Rigshospitalet, Aarhus University Hospital, Aalborg University Hospital, Zealand University Hospital, University of North Carolina at Chapel Hill, Brigham and Women's Hospital, Harvard University, Duke Medical Center, University Hospital Magdeburg, Boston Scientific (United States), Steno Diabetes Center Copenhagen
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,300
OpenAlex ID: W7154569002