Year: 2026
Type: article
Abstract: The skin is a highly organized immune organ in which resident non-immune cells cooperate with immune cells to maintain host defense and shape systemic adaptive immunity. A recent study revealed that a keratinocyte-intrinsic farnesyl pyrophosphate-transient receptor potential vanilloid 3 pathway transforms epidermal stress into interleukin-6- and chemokine-dependent signals that promote dendritic cell migration, T follicular helper-cell expansion and germinal center activity, thereby amplifying humoral immunity and autoimmunity.
Source: Immunity & Inflammation
Authors: Chaohuan Guo, George C. Tsokos
Institutions: Beth Israel Deaconess Medical Center, Harvard University
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funder: National Institutes of Health
Award: G9000329249
OpenAlex ID: W7154590571