Work

Diagnosis of Q-fever pneumonia by tNGS of bronchoalveolar lavage fluid in an elderly patient

Year: 2026

Type: article

Abstract: This study explores the value of targeted next-generation sequencing (tNGS) in the etiological diagnosis of unexplained pneumonia in elderly patients. A 76-year-old male patient presenting with fever and cough was initially diagnosed with lobar pneumonia. Bronchoalveolar lavage fluid (BALF) was analyzed using tNGS, which detected Coxiella burnetii (4 sequences), confirming the diagnosis. Treatment with moxifloxacin and doxycycline led to significant symptom improvement and complete resolution of pulmonary lesions on imaging. The results demonstrate that tNGS can provide rapid and accurate diagnosis of Coxiella burnetii pneumonia, offering important clinical insights.

Source: Diagnostic Microbiology and Infectious Disease

DOI: 10.1016/j.diagmicrobio.2026.117418

Authors: Zhao Dan, Mu Haijun, Gai Yanling

Institution: Qiqihar Medical University

Language: English

Topic: Bacterial Identification and Susceptibility Testing

Subfield: Clinical Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,290