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Case Report: Upadacitinib treatment for Behçet’s syndrome with intestinal damage

Year: 2026

Type: article

Abstract: We report the case of a 17-year-old male presenting with recurrent, debilitating oral and genital ulcerations. Diagnostic evaluation confirmed multisystemic Behçet's syndrome with multifocal intestinal involvement. Following the exclusion of infectious contraindications, the patient was initiated on upadacitinib (15 mg daily) as a primary systemic intervention. Remarkable clinical remission of mucocutaneous and gastrointestinal ulcerations was achieved within 1 month. Sustained improvement was observed during subsequent follow-up, suggesting that upadacitinib may serve as an effective therapy for multisystemic Behçet's syndrome in adolescent patients.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2026.1808317

Authors: Ling Yuan, Yingying Sun, Jianjun Yan

Institutions: Shandong Provincial Hospital, Shandong First Medical University

Language: English

Topic: Ocular Diseases and Behçet’s Syndrome

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801