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Remote stimulation of mitochondria and the antioxidant potential of thymocytes by weak non-ionizing non-thermal broadband pulsed electromagnetic fields in mouse

Year: 2026

Type: article

Abstract: Leading medical centers are currently considering pulsed electromagnetic therapy as a promising approach to prolong active life. Objective: The aim of this study was to investigate the effects of non-ionizing electromagnetic fields on mitochondrial activity and the state of the lipid peroxidation system, an antioxidant protection system in mice. Methodology: The studies were carried out on 60 BALB/c mice in accordance with bioethical standards and general ethical principles of animal experimentation. The animals were divided into 5 groups. The groups were placed in different rooms, standing at a considerable distance from each other. Experimental animals were exposed to non-invasive electromagnetic therapy device "TOR". The mitochondrial activity of thymocytes and the total antioxidant potential of the blood plasma were analyzed in all animals. Results: The study showed that weak non-ionizing non-thermal broadband pulsed electromagnetic fields (EMF) increased the antioxidant potential of mouse blood: at minimum exposure (1 min/h/10 nights) by almost 8% (p > 0.05), at maximum (5 min/h/10 nights) - by 20.6% (p< 0.05) - compared to the negative control group (young animals not exposed to EMF). The experiment confirms the dose-dependent stimulating effect of EMF on the mitochondria of thymocytes; at maximum exposure, the changes become statistically significant (increase in mitochondrial fluorescence by 29% compared to the negative control group, p< 0.05). Conclusion: The biological effects of non-ionizing electromagnetic fields are diverse. Due to their high penetrating power, they are able to affect deep-seated organs and tissues, thereby opening up new approaches in medicine and regenerative therapy that are cost-effective for patients and elicit cellular responses similar to physical exercise.

Source: Frontiers in Physiology

DOI: 10.3389/fphys.2026.1798354