Synthesis of (S)-4-Benzyl-3-butyl-1-(2-cycloheptylethyl)imidazolidine
Year: 2026
Type: article
Abstract: LiAlH4 reduction of tert-butyl (S)-butyl(1-((2-cycloheptylethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (1) gave imidazolidine 2, while treatment with LDA furnished the β-elimination product, cinnamamide 3. Both products were fully characterized. Reductive cyclization of N-alkylated-N-Boc-protected amino acid amides with LiAlH4 may be a viable synthetic method for trisubstituted chiral imidazolidines.
Source: Molbank
DOI: 10.3390/m2166
Institution: University of Ljubljana
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $603
OpenAlex ID: W7154613403