Impacts of stent characteristics on periprocedural ischemic events in elective PCI: the ALPHEUS-stents study
Year: 2026
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Stents characteristics can have a tremendous impact on the incidence of periprocedural ischemic events following percutaneous coronary intervention (PCI) in patients with chronic coronary syndrome (CCS). The ALPHEUS-stents study aimed to describe the association between stents lengths and characteristics on the occurrence of periprocedural ischemic events. METHODS: The study included patients with CCS undergoing elective PCI with at least one high-risk feature. The primary endpoint of the study was the composite of type 4a/4b myocardial infarction (MI) and periprocedural major myocardial injury evaluated at 48 h or discharge. First, we evaluated the association between total stent length and primary outcome using a multivariate logistic regression considering stent length as a continuous variable and adjusting for relevant covariates. Then we evaluated the associations between stent diameter, strut thickness, platform composition, polymer type, coating distribution and eluted drugs with the primary endpoint using a multivariable logistic regression model, with stent length categorized within the aforementioned subgroups. RESULTS: The primary endpoint occurred in 639 patients (35.8%). After adjustment, total stent length was significantly associated with the primary endpoint (adjusted Odds Ratio (aOR) 1.028 95%CI [1.028-1.029] per millimeter). No significant associations were observed across categories of stent diameter, strut thickness, platform composition or coating distribution. However, biolimus-eluting stents (aOR 1.051 [1.035-1.067], p = 0.006 vs other eluted drugs) were independently associated with an increased risk of the primary outcome. CONCLUSIONS: In patients undergoing elective PCI, the risk of periprocedural ischemic events is adequately captured by the total stent length. Biolimus-eluted stents might confer a higher risk of periprocedural ischemic events. CLINICALTRIALS: gov number: NCT02617290.
Authors: Louis Giovachini, Arnaud Ferrante, Paul Guedeney, Ghilas Rahoual, Niki Procopi, Olivier Barthelemy, Mathieu Kerneis, Michel Zeitouni, Mohamad El Kasty, Guillaume Cayla, Farzin Beygui, Grégoire Rangé, Zuzana Motovska, Mikael Laredo, Raphaëlle Dumaine, Grégory Ducrocq, Stéphanie Rouanet, Jean-Jacques Portal, Eric Vicaut, Gilles Montalescot, Johanne Silvain
Institutions: Inserm, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Centre Hospitalier Universitaire de Nîmes, Centre Hospitalier Universitaire de Caen Normandie, Les Hôpitaux de Chartres, Charles University, University Hospital Kralovske Vinohrady, Centre de Réadaptation Cardiaque Les Grands Prés, Université Paris Cité, Laboratoire de Recherche Vasculaire Translationnelle, Hôpital Bichat-Claude-Bernard, Hôpital Fernand-Widal, Université Paris 1 Panthéon-Sorbonne
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,970
Funder: AstraZeneca
OpenAlex ID: W7154620757