NF-κB signaling drives rapid skeletal muscle atrophy in patients with breast cancer: the cost of fighting cancer with chemotherapy
Year: 2026
Type: article
Abstract: By combining acute and chronic muscle biopsies from patients with breast cancer with complementary in vitro experiments, we determined that breast cancer chemotherapy triggers a rapid skeletal muscle atrophy driven by NF-κB activation and subsequent upregulation of the ubiquitin-proteasome system. Importantly, sulfasalazine fully prevented muscle atrophy by mitigating the imbalance in protein turnover, offering promising perspectives for clinical translation and improving patient prognosis.
Authors: Joris Mallard, Léa Debrut, Elyse Hucteau, Laura Somme, Hervé Bischoff, Fabien Moinard-Butot, Pierre Coliat, Abdelmalek Bendjama, Léo Weltzer, Alexandre Sharifi Tafreshi, Claudie Billand, Anouk Charlot, Lauréline Boutonnet, Gilles Laverny, Céline Keime, Fabrice Favret, Roland Schott, Xavier Pivot, Thomas J. Hureau, Allan F. Pagano
Institutions: Institut Strauss, Université de Strasbourg, Lyon 1 Université
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Funder: Agence Nationale de la Recherche
OpenAlex ID: W7154628232