Work

Revised Formal Total Synthesis of Dehydro-δ-Viniferin and Anigopreissin A

Year: 2026

Type: article

Abstract: This work presents a revised total synthesis of two pharmacologically relevant benzofurans using newly developed environmentally friendly methodologies. In particular, we focused on establishing improved synthetic routes to stilbene dimers under milder and more sustainable reaction conditions. During our investigations, we optimized an efficient Sonogashira coupling carried out in water, which, followed by a Suzuki-like reaction conducted in dimethyl carbonate (DMC) in the absence of any transition metals, served as the key step for the synthesis of the benzofuran core.

Source: Organics

DOI: 10.3390/org7020017

Authors: Alessandro Santarsiere, Marianna Volgare, Lucia Chiummiento

Institution: University of Basilicata

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,207

Funder: European Commission