Plasma metabolomics analysis in murine prerenal azotemia reveals changes in energy substrates, amino acid metabolism, and uremic toxins
Year: 2026
Type: article
Abstract: We completed the first untargeted plasma metabolomics analysis in a murine model of prerenal azotemia (PRA) and demonstrate that PRA has systemic consequences with numerous significantly altered metabolites and pathways. By comparing the metabolite signature to that of acute tubular injury (ATI), novel insights into the potential adverse consequences of PRA and potential methods to distinguish PRA from ATI were identified.
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G5332584854, G8796557663
OpenAlex ID: W7154634697