Work

Isoxanthohumol and Its Derivatives: Antioxidant Activity and Effects on the Gut Microbiota

Year: 2026

Type: article

Abstract: ) that is gaining increasing recognition for its potential biological effects. Despite numerous studies on its precursor, xanthohumol, studies on IX remain limited. Of particular interest is its metabolism, particularly its biotransformation by gut microbiota to 8-prenylnaringenin (8-PN), a potent phytoestrogen, which indicates the complex nature of its biological activity and potential health implications. This review summarizes the current state of knowledge on IX and its derivatives, covering their microbial metabolism, their impact on the gut microbiome, and the metabolic consequences of this conversion. Furthermore, it examines the relationship between the molecular structure of IX and its derivatives and their biological activity, highlighting existing research gaps and the need for further research on the safety and therapeutic potential of these compounds.

Source: Molecules

DOI: 10.3390/molecules31081311

Authors: Renata Choińska, Justyna Nasiłowska, Adrian Wojtczak, Włodzimierz Lewandowski, Renata Świsłocka

Institutions: Institute of Agricultural and Food Biotechnology, Bialystok University of Technology

Language: English

Topic: Hops Chemistry and Applications

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258