Work

Obesity as the Upstream Driver of Inflammation and Insulin Resistance in Hyperuricaemia

Year: 2026

Type: article

Abstract: reported that systemic inflammation (modified inflammation [mINFLA] score) and insulin resistance (triglycerideglucose [TyG] index) are independently and jointly associated with hyperuricaemia (HUA) risk, with the TyG index mediating approximately 15% of the inflammation-HUA relationship.The authors provide a thorough analysis of these interacting pathways.This correspondence proposes that for a substantial subset of individuals with overweight or obesity, adiposity may function not as another concurrent pathway but as the unifying upstream driver of both inflammation and insulin resistance in HUA.

Source: Endocrinology Diabetes & Metabolism

DOI: 10.1002/edm2.70224

Author: Mohammad Riashad Monjur

Institutions: Camden and Campbelltown Hospitals, South Western Sydney Local Health District

Language: English

Topic: Gout, Hyperuricemia, Uric Acid

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,280