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Recent Developments in (Archaeal) Pyrrolysine and Selenocysteine Specification and Metabolism

Year: 2026

Type: preprint

Abstract: synthetase. The 2 aa further differ in how message context influences translation. Translation of UGA as selenocysteine relies heavily on the presence of a specific messenger RNA (mRNA) sequence found in the transcript. In contrast, local message context stimulates, but is not required for, relatively efficient translation of UAG as pyrrolysine.

Source: Cold Spring Harbor Perspectives in Biology

DOI: 10.1101/cshperspect.a041979

Authors: Nils Peiter, Michael Rother, Joseph A. Krzycki

Institutions: Technische Universität Dresden, The Ohio State University

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W7154691330

Cites: 127

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Related to: 10