Non-viral targeted integration at the CISH locus enables CAR-NK cell engineering with enhanced anti-tumor activity
Year: 2026
Type: article
Abstract: , extended persistence, and reduced exhaustion. Together, these findings highlight CLICK as a highly efficient and versatile platform for non-viral CAR-NK cell engineering, offering a scalable approach for next-generation allogeneic immune cell therapies.
Source: Molecular Therapy Oncology
Authors: Jiao Wang, Yao Sun, Jakob Starzyk, Fei Wang, Xin Dong, Richard Shan, Xuemei He, Keqiang Xie, Guozhu Xie, Hao Wu
Institutions: Nanfang Hospital, Southern Medical University
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,900
OpenAlex ID: W7154702739