Work

A Novel Pyrrole Acylsulfonamide, Compound 42 , as a Dual URAT1/GLUT9 Inhibitor: Potent Urate-Lowering Efficacy, Reduced Off-Target Effects, and Promising Druggability for Hyperuricemia

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.6c00005

Authors: Zhenqian Wang, Xiaoyu Shi, Zitao Guo, Zhenkun Wu, Yuexin Xu, Mingyu Yang, Mei Wang, Qian Yang, Ting Wu, Jianxin Pang, Fan Yi, Peng Zhan, Xinyong Liu

Institutions: Shandong University, Southern Medical University, Peking University, Tianjin Institute of Pharmaceutical Research (China), State Key Laboratory of Natural and Biomimetic Drugs

Language: English

Topic: Gout, Hyperuricemia, Uric Acid

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funder: National Natural Science Foundation of China

Awards: G5336389093, G6821817792, G8339366813, G8386147943

OpenAlex ID: W7154702953

FWCI: 18.02

Cites: 35

Cited by: 4

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