Dietary total antioxidant capacity alleviates inflammatory bowel disease-related surgery, gastrointestinal cancer, and mortality risks among middle-aged and older individuals
Year: 2026
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: This study aimed to investigate the association between dietary total antioxidant capacity (TAC) and the risks of clinical outcomes, including surgery, gastrointestinal cancer, and mortality, among middle-aged and older individuals with IBD. DESIGN: Nationwide prospective cohort study. SETTING AND PARTICIPANTS: We included middle-aged and older participants with IBD when recruited in the UK Biobank. MEASUREMENTS: Dietary TAC was calculated by the oxygen radical absorbance capacity from the food by repeated dietary recalls. The outcomes representing IBD prognosis include IBD-related surgery, gastrointestinal cancer, and death events. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazard models. Polymorphism of antioxidant-related enzymes genes was ascertained via genotype data. RESULTS: With a median follow-up period of 10.9 years, we documented 174 cases of IBD-related surgery, 52 gastrointestinal cancer, and 189 death events among 2487 IBD participants. Compared to the lowest quartile of dietary TAC, participants in the highest quartile presented lower risks of IBD-related surgery (HR 0.53; 95% CI 0.34-0.84; P-trend = 0.005) and all-cause mortality (HR 0.61; 95% CI 0.39-0.96; P-trend = 0.014). Compared to the lowest decile, participants in the higher deciles of dietary TAC had a lower risk of gastrointestinal cancer (HR 0.39; 95% CI 0.19-0.83; P = 0.014). We also found genetic variants in catalase gene CAT and antioxidant transporter gene SLC2A14 modified the association between dietary TAC and IBD prognosis. CONCLUSIONS: Higher dietary TAC was associated with better prognosis of middle-aged and older individuals with IBD, including lower risk of related surgery, gastrointestinal cancer, and all-cause mortality, suggesting the importance of adherence to high-TAC diet in IBD management.
Institutions: Westlake University, Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine, Third Xiangya Hospital, Shanghai Jiao Tong University, Ruijin Hospital, Karolinska Institutet, Philadelphia VA Medical Center, University of Pennsylvania, Örebro University Hospital, Uppsala University, Central South University, Second Affiliated Hospital of Zhejiang University, Zhejiang University
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,450
Funders: National Natural Science Foundation of China, Cancerfonden, Central South University, China Postdoctoral Science Foundation, Hjärt-Lungfonden, Vetenskapsrådet, Natural Science Foundation of Hunan Province, Xiangya Hospital, Central South University, Science Fund for Distinguished Young Scholars of Zhejiang Province
OpenAlex ID: W7154707086