Maternal Cytomegalovirus Serology Results by Geographic Region in a Large Multicenter US Study
Year: 2026
Type: article
Abstract: Congenital cytomegalovirus (CMV) infection, due to both nonprimary and primary maternal infection, affects nearly 1% of neonates. In conducting a randomized trial of hyperimmune globulin for prevention of congenital CMV infection, we screened over 200,000 pregnancies across the United States for evidence of prior or primary CMV infection and evaluated their geographic variation. Although the majority were seropositive, seroprevalence and primary infection risk varied significantly by geographic region, with seroprevalence the highest (88%) and primary infection (0.2%) the lowest in the Southwest. This variation in seroprevalence by geography may inform planning of public health measures to decrease congenital CMV.
Authors: Brenna L Hughes, Cora MacPherson, Dwight J Rouse, George R Saade, Mara J Dinsmoor, Uma M Reddy, Robert Pass, Donna Allard, Gail Mallett, Rebecca G Clifton, Cynthia Gyamfi-Bannerman, Michael W Varner, William H Goodnight, Alan T N Tita, Maged M Costantine, Geeta K Swamy, Kent D Heyborne, Edward K Chien, Suneet P Chauhan, Yasser Y El-Sayed, Brian M Casey, Samuel Parry, Hyagriv N Simhan, Peter G Napolitano, George A Macones
Institutions: Brown University, George Washington University, The University of Texas Medical Branch at Galveston, Northwestern University, Northwestern University, Northwestern Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, University of Alabama at Birmingham, Columbia University Irving Medical Center, Columbia University, University of Utah, Utah Department of Health, University of Utah Health Care, University of North Carolina at Chapel Hill, The Ohio State University, Duke University, Duke University Hospital, University of Colorado Anschutz, Case Western Reserve University, Memorial Hermann, Stanford Medicine, Stanford University, The University of Texas Southwestern Medical Center, Hospital of the University of Pennsylvania, University of Pennsylvania, University of Pittsburgh, Madigan Army Medical Center, The University of Texas at Austin
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7154846508