Single-nucleus profiling reveals hepatocyte identity and immune features associated with corticosteroid response in severe alcohol-related hepatitis
Year: 2026
Type: article
Study design: Observational Study
Source: Journal of Hepatology
Authors: Lukas Van Melkebeke, Markus Boesch, Tessa Ostyn, Wenxin Huang, Cansu Akkaya, Matthias van Sligtenhorst, Dania El Abyad, Fateme Safaeifard, Alexander Dumarey, Marie Wallays, Bram Boeckx, Rita Feio-Azevedo, Lena Smets, Thierry Gustot, Eric Trépo, Christophe Moreno, Antonella Putignano, Luc Lasser, Isabelle Colle, Pierre Deltenre, Astrid Marot, Baki Topal, Eveline Claus, Lawrence Bonne, Geert Maleux, Colinda Scheele, Tim Hendrikx, Frederik Nevens, Hannelie Korf, Tania Roskams, Alexandre Denadai-Souza, Diether Lambrechts, Olivier Govaere, Schalk Van der Merwe, Jef Verbeek
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Harnessing Single-Cell and Spatial Transcriptomics to Uncover Novel Insights into Intestinal Barrier Breach in Cirrhosis, G4611285557, Deciphering the molecular pathways needed to restore monocyte dysfunction during Acute-on-chronic liver failure, G5974908517, Elucidating Macrophage Heterogeneity and Immunometabolism in Non-alcoholic Fatty Liver Disease, Determining the role of hepatic and circulatory Immune Cells on a single cell level in the Onset and Treatment of severe Alcoholic Hepatitis: The DICOTAH study., G7871439156, Non-Alcoholic Fatty Liver Disease- the role of adipose tissue in the development of NASH: a translational study
OpenAlex ID: W7154946461