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Effectiveness of fidaxomicin in preventing recurrence after initial community-associated Clostridioides difficile infection

Year: 2026
Type: article
Study design: Observational Study
Abstract: Using population-based surveillance from 2020 to 2024, we examined recurrence through 180 days among adults with initial community-associated Clostridioides difficile infection (CDI). Fidaxomicin was associated with a 50% lower risk of recurrence compared with vancomycin. These findings are consistent with current guideline recommendations and are relevant to outpatient management of initial CDI.
DOI: 10.1017/ash.2026.10379
Authors: Adam Hawco, Christopher Myers, Runda Dahhan, Christine Hurley, Edwin van Wijngaarden, Christina Felsen, Ghinwa Dumyati
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,719
Award: NYS EMERGING INFECTIONS PROGRAM - THE NEW YORK STATE EMERGING INFECTIONS PROGRAM (NYSEIP) WAS FORMED IN 1997 VIA A PARTNERSHIP BETWEEN THE NEW YORK STATE DEPARTMENT OF HEALTH’S (NYSDOH) CENTERS FOR COMMUNITY HEALTH (CCH) AND ENVIRONMENTAL HEALTH (CEH) AND WADSWORTH CENTER LABORATORIES (WC) AND THE UNIVERSITY OF ROCHESTER MEDICAL CENTER (URMC), CENTER FOR COMMUNITY HEALTH. THIS GROUP OF COLLABORATORS SUPPORTS THE NYSEIP IN EFFORTS TO CONDUCT ACTIVE POPULATION-BASED SURVEILLANCE ACTIVITIES, APPLIED PUBLIC HEALTH EPIDEMIOLOGIC AND LABORATORY PROJECTS, AND IMPLEMENTS AND EVALUATES PREVENTION/INTERVENTION PROJECTS FOR EMERGING INFECTIOUS DISEASES. LEVERAGING THE STRENGTHS OF THE NYSDOH AND URMC, HAS ENABLED THE NYSEIP TO HAVE MUCH GREATER FLEXIBILITY TO RAPIDLY RESPOND TO CROSSCUTTING REQUESTS FOR NEW EIP SURVEILLANCE INITIATIVES AND SPECIAL PROJECTS. THE NEW YORK STATE DEPARTMENT OF HEALTH (NYSDOH) HAS THE STATUTORY AUTHORITY AND RESPONSIBILITY TO CONDUCT DISEASE SURVEILLANCE, OVERSEE OUTBREAK INVESTIGATIONS, AND PERFORM FOOD AND WATER INSPECTIONS AT REGULATED FACILITIES. ALL PHYSICIANS, HOSPITALS, AND LICENSED CLINICAL LABORATORIES ARE REQUIRED TO REPORT CASES OR SUSPECT CASES OF OVER 60 COMMUNICABLE DISEASES AND CONDITIONS. NYSDOH IS PROPOSING AN CATCHMENT AREA TO INCLUDE 50 OF THE 57 NEW YORK STATE COUNTIES (EXCLUDES NEW YORK CITY) IN TOTAL, EXPANDED TO 14 CENTRAL NEW YORK (CNY) COUNTIES, AND TWO LONG ISLAND COUNTIES, AND THE PROPOSED NEW LHDS (IF FUNDED): BROOME, CAYUGA, CHENANGO, CORTLAND, HERKIMER, JEFFERSON, LEWIS, MADISON, ONEIDA, ONONDAGA, OSWEGO, ST. LAWRENCE, TIOGA, TOMPKINS (IMMEDIATE FOODNET EXPANSION AND INVASIVE PNEUMOCOCCAL DISEASE IN KIDS <5) NASSAU AND SUFFOLK (EXPLORE FEASIBILITY IN YEAR 2 OF FOODNET EXPANSION AND INVASIVE PNEUMOCOCCAL DISEASE IN KIDS <5). THE NYSDOH WILL BE APPLYING FOR THE FOLLOWING COMPONENTS OF THIS COMPETITIVE APPLICATION: • A. INFRASTRUCTURE AND DATA MODERNIZATION • B. SURVEILLANCE AND REPORTING 1 • C. SURVEILLANCE AND REPORTING 2 • RESPIRATORY VIRUS HOSPITALIZATION SURVEILLANCE NETWORK (RESP-NET) O D. INFLUENZA HOSPITALIZATION SURVEILLANCE NETWORK (FLUSURV-NET) O E. RESPIRATORY SYNCYTIAL VIRUS (RSV)- ASSOCIATED HOSPITALIZATIONS (RSV-NET) O F. CORONAVIRUS DISEASE 2019 (COVID-19)- ASSOCIATED HOSPITALIZATION SURVEILLANCE (COVID-NET) • G. ACTIVE BACTERIAL CORE SURVEILLANCE (ABCS) • H. FOODBORNE DISEASE ACTIVE SURVEILLANCE NETWORK (FOODNET) • I. HEALTHCARE-ASSOCIATED INFECTIONS- COMMUNITY INTERFACE (HAIC) • J. HPV VACCINE IMPACT MONITORING PROJECT (HPV-IMPACT) • K. LYME AND OTHER TICKBORNE DISEASES (TICKNET) • N. MPOX VACCINE EFFECTIVENESS EVALUATION
OpenAlex ID: W7154946933
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Cites: 12
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Related to: 10