Desymmetrization of Pseudo ‐ para Diformyl[2.2]Paracyclophane via Brønsted Acid‐Catalyzed Reductive Amination
Year: 2026
Type: article
Abstract: Access to planar chiral molecules remains a longstanding challenge in asymmetric synthesis. Enantiopure [2.2]paracyclophanes are particularly attractive due to their broad applications in medicinal chemistry, asymmetric catalysis, and materials science. Herein, we present a highly stereoselective approach for the desymmetrization of prochiral pseudo ‐ para diformyl[2.2]paracyclophanes, enabled by chiral Brønsted acid‐catalyzed reductive amination. This method furnishes planar chiral structures with excellent enantiocontrol and broad substrate scope. Moreover, the resulting products can be readily modified, underscoring the utility of this approach as a versatile platform for the asymmetric synthesis of planar chiral [2.2]paracyclophane derivatives.
Source: Advanced Synthesis & Catalysis
DOI: 10.1002/adsc.70433
Institution: Charles University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,650
OpenAlex ID: W7155013461