Work

Wortmannin exhibits anticancer activity in oral cancer cell line by targeting PI3K, AKT and mTOR pathway.

Year: 2026

Type: article

Abstract: Objective: Although the molecular mechanism by which wortmannin exerts its anticancer properties in solid tumors is not fully understood, particularly in the context of oral cancer where research is scarce, this study seeks to explore how wortmannin disrupts the PI3K pathway, consequently affecting the proliferation and apoptosis of human oral cancer cells. Materials and Methods: experiments examined Viability Assay, apoptosis, cell cycle, Reactive Oxygen Species ROS and MMP levels, and gene expression. Results: expression increased. Conclusion: research are needed.

Source: PubMed

DOI: 10.22038/ajp.2025.26226

Authors: Gauri Kumbhar, Poonam Suryawanshi, Vaibhav Ladke

Institutions: Dr. D.Y. Patil Vidyapeeth, Pune, Dr D Y Patil Dental College & Hospital, Dr. D. Y. Patil Medical College, Hospital and Research Centre

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7155030995