Work

Investigating the coupled effects of stiffness and stretch on the trabecular meshwork cells using a hydrogel-integrated microfluidic system

Year: 2026

Type: article

Abstract: A hydrogel-integrated microfluidic chip applies tunable substrate stiffness and equibiaxial stretch to trabecular meshwork cells. Both cues interdependently regulated phenotypic and ECM markers; glaucomatous cells showed marker-specific divergence.

Source: Biomaterials Science

DOI: 10.1039/d6bm00705h

Authors: Kanghoon Choi, Minju Kim, Monika Lakk, Fiona S. McDonnell, David Krizaj, Jungkyu Kim

Institution: University of Utah

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Research to Prevent Blindness, University of Utah, National Eye Institute

Awards: Cellular and Molecular Mechanisms that Contribute to Pressure-Induced Retinal Inflammation and Pathology, Molecular mechanisms of mechanotransduction in the aqueous outflow pathway, Vision Research Training Grant at the University of Utah, University of Utah Core Vision Research Grant