Preoperative Albumin to Alkaline Phosphatase Ratio Correlates to Postoperative Complications After Radical Gastrectomy in Elderly Gastric Cancer Patients
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background The role of albumin-to-alkaline phosphatase ratio (AAPR) in predicting complications in elderly gastric cancer (GC) patients is unclear.Methods This retrospective study included 358 elderly GC patients (≥60 years of age) who underwent laparoscopic radical gastrectomy between 2020 and 2023. Based on AAPR values, patients were categorized into high (≥0.545) and low (<0.545) AAPR groups based on receiver operating characteristic (ROC) analysis. Clinical characteristics, surgical parameters, and postoperative outcomes were collected. The incidence and severity of complications were compared between groups. Independent risk factors for postoperative complications were identified using multivariate logistic regression.Results Among the 358 patients, 105 (29.3%) experienced postoperative complications. The low AAPR group had a significantly higher overall complication rate (50.4% vs. 15.7%, p < 0.001) and a greater proportion of severe complications. Multivariate analysis identified low AAPR as an independent predictor of postoperative complications (OR = 0.284, 95% CI: 0.158–0.502, p < 0.001), alongside TNM stage III-IV, ASA grade III, and prolonged operative time. Patients with low AAPR also had significantly longer hospital stays, higher ICU re-admission rates, and increased unplanned 30-day re-admissions (p < 0.001).Conclusions Preoperative AAPR is a key predictor of postoperative complications in elderly GC patients undergoing laparoscopic gastrectomy.
Source: Journal of Investigative Surgery
Authors: Shuangzhen Bao, Xinying Wang, Jiangang Zhao
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,970
OpenAlex ID: W7155033836