Work

Dopaminergic modulation of low- and high-spontaneous rate type I auditory nerve fiber activity

Year: 2026

Type: article

Abstract: Efferent lateral olivocochlear fibers originating in the brainstem and projecting into the mammalian cochlea inhibit auditory nerve fiber activity via dopaminergic inputs. The study here shows that dopamine affects all subtypes of auditory nerve fibers, with low and high spontaneous rates, via direct stimulation of a D1-like receptor. Data do not support an effect of D2-like receptors on ANF firing rate.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00484.2025

Authors: Daniel O. J. Reijntjes, Marco Manca, Jingjing Sherry Wu, Philippe F. Y. Vincent, Kushal Sharma, Eunyoung Yi, Grace Tate, Kevin J. Psoter, Elisabeth Glowatzki

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Harvard University, Sound Pharmaceuticals, Inc. (United States), Mokpo National University

Language: English

Topic: Hearing, Cochlea, Tinnitus, Genetics

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Research Foundation of Korea, National Institutes of Health, National Institute on Deafness and Other Communication Disorders

Awards: G3319701399, G4532353906, AFFERENT SYNAPTIC TRANSMISSION IN THE MAMMALIAN COCHLEA, G5693376701, Synaptic mechanisms underlying vestibular nerve fiber activity

OpenAlex ID: W7155052216

FWCI:

Cites: 66

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