Direct C–N Coupling of Aromatic Aldehydes with Amines by H 2 O 2 for Synthesis of Amides at Room Temperature
Year: 2026
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide In this paper, we report a new mild and environmentally friendly approach for the direct C–N coupling of aromatic aldehydes with amines at room temperature to synthesize amides in which H 2 O 2 serves as the oxidizing agent without the need for a catalyst. Investigation into substrate scope showed that the strategy exhibits good functional group tolerance. Under the optimal reaction conditions, the direct C–N coupling of aromatic aldehydes with secondary amines affords a series of amide products with moderate to high yields of 67%–95%, along with the sole byproduct of water. Additionally, a maximum isolated yield of 90% is achieved in the gram-scale reaction. Finally, a plausible reaction mechanism is proposed via a series of parallel experiments.
Source: ACS Omega
Authors: Meng-Yun Zhao, Meng-Han Li, Guo-Zhi Han
Institution: Nanjing Tech University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,935
OpenAlex ID: W7155057580