Work

Pharmacist-led interventions in hematological malignancies: a systematic review of clinical, process and economic outcomes

Year: 2026

Type: review

Abstract: Background: Pharmacist-led interventions are increasingly integrated into hematology-oncology care to address complex pharmacotherapy and medication safety challenges. However, their impact within hematological malignancies has not been comprehensively synthesized across clinical, process-related, and economic domains. Methods: A systematic review was conducted to evaluate pharmacist-led interventions in patients with hematological malignancies across inpatient and outpatient settings. Thirty-three studies were included. Owing to substantial heterogeneity in study design, interventions, and outcome definitions, a structured qualitative synthesis was performed, with findings grouped by clinical, process-related, and economic outcomes. Results: = 8). Pharmacist-led interventions most consistently improved medication management processes, including identification and resolution of drug-related problems, drug interaction management, and care coordination, with high acceptance rates of pharmacist recommendations. Several studies also reported improvements in medication adherence, toxicity management, and selected patient-reported outcomes; however, findings for disease response, survival, and hospitalization were heterogeneous and not consistently statistically significant. Economic evaluations were limited but suggested potential cost savings and favorable returns on investment associated with pharmacist involvement. Conclusion: Pharmacist-led interventions in hematology-oncology care improve medication management processes and may contribute to better adherence and medication safety. However, evidence for effects on clinical and economic outcomes remains limited and heterogeneous, highlighting the need for well-designed prospective studies using standardized outcome measures. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251147239, identifier CRD420251147239.

Source: Frontiers in Pharmacology

DOI: 10.3389/fphar.2026.1779201

Authors: Amna Mohamed, Bushra Salman, Raya Al Maskari, Khalil Al-Farsi, Mohamed A. Yassin

Institutions: University of Technology and Applied Sciences, Sultan Qaboos University, National Center for Cancer Care and Research, Hamad Medical Corporation, Qatar University

Language: English

Topic: Pharmacy and Medical Practices

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801