Work

Cutaneous Rosai–Dorfman disease involving the left ear responsive to systemic glucocorticoid: a case report

Year: 2026

Type: article

Abstract: A 49-year-old man presented with a 1-year history of red facial nodules and a 3-month history of left-sided hearing decline. A biopsy revealed mixed inflammation and emperipolesis of histiocyte-like cells. An immunohistochemical analysis demonstrated that the histiocyte-like cells were positive for S100 and CD68 PGM1 and negative for CD1a and CD207, confirming the diagnosis of cutaneous Rosai–Dorfman disease (CRDD). The initial treatment consisted of oral prednisone acetate combined with methotrexate. Due to limited efficacy and adverse effects, methotrexate was discontinued, and prednisone acetate monotherapy was used. After 2 months, the patient’s skin lesions gradually resolved, and hearing improved. This case demonstrates that CRDD involving the ear can lead to hearing recovery following systemic corticosteroid therapy.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2026.1797006

Authors: Xiaoxue Zhuo, Zhuoma Dangzeng, Peiyu Zhou, Tingting Wang, Lin Wang

Institutions: Sichuan University, West China Medical Center of Sichuan University, West China Hospital of Sichuan University

Language: English

Topic: Histiocytic Disorders and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801