Work

Case Report: Rare malignant teratoma in the right posterior thigh

Year: 2026

Type: article

Abstract: Malignant teratomas are rare germ cell tumors characterized by undifferentiated embryonic components, exhibiting invasive and metastatic potential. While teratomas commonly arise in the gonads, such as the ovaries and testes, as well as midline locations like the sacrococcygeal region and mediastinum, the occurrence of a malignant teratoma in the femur (right femur) is exceedingly rare, with limited research available. We report the case of a 19-year-old female presented with a subcutaneous mass in the right posterior thigh for 2 months, which was later confirmed as immature teratoma (CK5/6 + , CK8/18 + , CK7 + , CK20 + , villin + , S-100 + , Syn + , GFAP + , NF + , Neu-N + , CgA + , CD99 + , Dasmin - , SMA - ) with higher expression of Ki-67. Two key like pathogenic germline variants were revealed through whole exome sequencing: BLM c.2634C>A (p. Tyr878 *) and MSH6 c.3986C>A (p. Ser1329 *). This report provides information on the clinical course of rare malignant teratoma in the right posterior thigh, including treatment strategy and prognosis.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2026.1673801

Authors: Yanhui Shi, Pengfei Leng, Xiaohua Tan, Linlin Liu, Miaoqing Zhao

Institutions: Shandong Tumor Hospital, Shandong First Medical University, People's Liberation Army 401 Hospital, Qingdao University

Language: English

Topic: Testicular diseases and treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801