Work

Impact of tongue exercise on hypoglossal axis survival, structure, and output in a rodent model of hypoglossal motor neuron degeneration

Year: 2026

Type: article

Abstract: Intralingual injections of CTB-SAP result in decreased XII motor neuron survival and degenerative changes in the XII nerve consistent with what is seen in many MNDs. Although these deficits are not mitigated by tongue exercise, we do observe increased microglial fractional area/density in the XII nucleus of CTB-SAP + exercise rats. In addition, deficits in XII motor output are mitigated by tongue exercise, indicating neuroplasticity despite significant loss of XII motor neurons and XII nerve degeneration.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00631.2024

Authors: Amy N. Keilholz, Stephanie Lopez, Minasadat Attari, Nguyen P. Nguyen, Jay Henry, Catherine L. Smith, Ashley Feldberg, Kate L. Osman, Mojgan Golzy, Filiz Bunyak, Teresa E. Lever, Nicole L. Nichols

Institutions: University of Missouri, Palmer College of Chiropractic

Language: English

Topic: Amyotrophic Lateral Sclerosis Research

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Foundation for the National Institutes of Health, University of Missouri, National Institutes of Health, National Heart, Lung, and Blood Institute

Awards: G2364186885, G5560688786, Harnessing tongue exercise to enhance neuroplasticity and preserve upper airway function in a novel model of hypoglossal motor neuron degeneration, Postdoctoral Training in Comparative Medicine

OpenAlex ID: W7155084587

FWCI:

Cites: 67

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